Tuesday, September 4, 2012

Using RNA nanotechnology to treat cancers and viral infections: New study shows promise

ScienceDaily (Sep. 4, 2012) ? A new study by University of Kentucky researchers shows promise for developing ultrastable RNA nanoparticles that may help treat cancer and viral infections by regulating cell function and binding to cancers without harming surrounding tissue.

The study, published in Nano Today, was carried out in the laboratory of Peixuan Guo, the William S. Farish Endowed Chair in Nanobiotechnology at the UK Markey Cancer Center, in collaboration with Dr. Mark Evers, director of the UK Markey Cancer Center.

The study uses RNA (ribonucleic acid) as a building block for the bottom-up fabrication of nanostructures. Using the RNA nanotechnology pioneered by Guo, the researchers constructed ultrastable X-shaped RNA nanoparticles using re-engineered RNA fragments to carry up to four therapeutic and diagnostic modules. Their RNA nanoparticles can include small interfering RNA for silencing genes, micro-RNA for regulating gene expression, aptamer for targeting cancer cells, or a ribozyme that can catalyze chemical reactions.

The study demonstrated that regulation of cellular functions progressively increased with the increasing number of functional modules in the nanoparticle.

"RNA nanotechnology is an emerging field, but the instability and degradation of RNA nanoparticles have made many scientists flinch away from the research in RNA nanotechnology," Guo said. "We have addressed these issues, and now it is possible to produce RNA nanoparticles that are highly stable both chemically and thermodynamically in the test tube or in the body with great potential as therapeutic reagents."

The RNA nanoparticles displayed several favorable attributes: polyvalent nature, which allows simultaneous delivery of multiple functional molecules for achieving synergistic effects; modular design, which enables controlled self-assembly with defined structure; thermodynamically stable, which keeps the RNA nanoparticles intact in animal and human circulation systems, where they exist at very low concentrations; and chemically stable, which makes the nanoparticles resistant to RNase (an enzyme, which cleaves RNA) digestion in the blood serum.

"A major problem with cancer treatments is the ability to more directly and specifically deliver anti-cancer drugs to cancer metastases," Evers said. "Using the nanotechnology approach that Peixuan Guo and his group have devised may allow us to more effectively treat cancer metastasis with fewer side effects compared to current chemotherapy."

In addition to Evers and Markey team member Dr. Piotr Rychahou, Guo's research team at UK also includes Farzin Haque, first author on the paper; Dan Shu; Yi Shu; and Luda Shlyakhtenko.

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The above story is reprinted from materials provided by University of Kentucky.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Farzin Haque, Dan Shu, Yi Shu, Luda S. Shlyakhtenko, Piotr G. Rychahou, B. Mark Evers, Peixuan Guo. Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers. Nano Today, 2012; 7 (4): 245 DOI: 10.1016/j.nantod.2012.06.010

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/biochemistry/~3/UzzzKDfqsVs/120904095848.htm

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Friday, August 31, 2012

Romney asks US to 'turn the page' on Obama

Republican presidential nominee Mitt Romney addresses delegates before speaking at the Republican National Convention in Tampa, Fla., on Thursday, Aug. 30, 2012. (AP Photo/David Goldman)

Republican presidential nominee Mitt Romney addresses delegates before speaking at the Republican National Convention in Tampa, Fla., on Thursday, Aug. 30, 2012. (AP Photo/David Goldman)

Balloons fall as Republican presidential nominee Mitt Romney and Republican vice presidential nominee, Rep. Paul Ryan's families take the stage at the Republican National Convention in Tampa, Fla., on Thursday, Aug. 30, 2012. (AP Photo/Charles Dharapak)

Republican presidential nominee Mitt Romney and Republican vice presidential nominee, Rep. Paul Ryan, left, wave following Romney's speech during the Republican National Convention in Tampa, Fla., on Thursday, Aug. 30, 2012. (AP Photo/Charlie Neibergall)

Republican presidential nominee Mitt Romney addresses delegates before speaking at the Republican National Convention in Tampa, Fla., on Thursday, Aug. 30, 2012. (AP Photo/Jae C. Hong)

Republican presidential nominee Mitt Romney addresses the Republican National Convention in Tampa, Fla., on Friday, Aug. 31, 2012. (AP Photo/Patrick Semansky)

(AP) ? Lifted by a show of Republican unity that once seemed so distant, Mitt Romney plunged into the presidential campaign's final 67 days focused more than ever on jobs and the economy, and depicting President Barack Obama as a well-meaning but inept man who must be replaced.

"America has been patient," he told the nation. "Americans have supported this president in good faith. But today, the time has come to turn the page."

Obama, who will hold his own convention next week, served notice that he will use his powers of incumbency to make Romney's mission hard. Obama planned to visit a Texas military base exactly two years after declaring the end of the U.S. combat mission in Iraq, the war that haunts the last Republican president. This, as Democrats prepare to gather in Charlotte, N.C., for Obama's convention.

Romney capped a high-energy night closing the Republican National Convention with a spirited and unusually personal speech infused with his family life, touching on his Mormon faith and recounting his youth. The cheers were loud and frequent, surely music to the ears of a candidate who struggled throughout the bruising primary season and beyond to bury doubts among many in his party that he was the authentic conservative in the field.

"Now is the time to restore the promise of America," Romney declared to a nation struggling with unemployment and the slowest economic recovery in decades.

Polls suggest a to-the-wire campaign finish. The two men will spend the next 10 weeks in a handful of competitive states, none more important than Florida and Ohio, and meet in one-on-one debates where the stakes could hardly be any higher.

The campaign themes are mostly set. Romney depicts the president as a once-inspiring but disappointing figure who doesn't understand job-creation or ordinary Americans' frustrations. Democrats portray Romney as a man shifting ever rightward in the absence of core convictions, and a wealthy plutocrat who can't relate to the middle class.

Hanging over the campaign is a big number: the nation's 8.3 percent unemployment rate. It is Obama's biggest impediment to a second term. Republicans seem to be banking on the notion that it will bring Obama down if Romney simply presents himself as a competent alternative.

Strikingly absent from Romney's campaign, including the three-day convention in Tampa, were detailed explanations of how he would tame deficit spending while also cutting taxes and expanding the armed forces. He seems to be asking voters to trust his ability to create jobs and to make tough, unpopular decisions later.

Romney used his biggest moment yet in the spotlight, Thursday's televised acceptance speech, to put a softer glow on his business record and to make short work of a conservative checklist that is now less important as he pursues swing voters.

He briefly hailed "the sanctity of life," but did not mention "abortion," illegal immigration, or even Ronald Reagan by his first name.

Romney's speech also omitted many of the sharp barbs that he and his allies often throw at Obama.

"I wish President Obama had succeeded, because I want America to succeed," Romney said. "But his promises gave way to disappointment and division. ... We deserve better."

He repeated his claim that Obama can't lead America out its economic doldrums because he has no business background.

"Jobs to him are about government," Romney said.

The relatively toned-down rhetoric was a shift from Romney's taunt, only two weeks ago, of "Mr. President, take your campaign of division and anger and hate back to Chicago."

Thursday's gentler tone by Romney might simply be a nod to reality. Polls repeatedly find that voters find Obama more likable than Romney. Romney's convention message was: It's OK to like Obama even as you fire him.

Of course other top Republicans, and Romney himself, might revert to ripping into Obama, especially if they don't see polls moving in Romney's direction soon in the 10 or so states up for grabs.

Democrats hope their convention in Charlotte will, at a minimum, neutralize any GOP bounce out of Tampa.

Obama seemed equally willing to avoid bombastic rhetoric for a while. He told Time magazine he hoped his re-election would help end the political stalemate in Washington, much like "popping a blister."

The president also said he wants to do a better job of explaining how his policies will help boost the economy.

Obama planned to campaign this weekend in Ohio, Colorado and Iowa.

Romney planned to campaign Friday in Virginia, Saturday in Ohio and both days in Florida before taking a couple of days to rest while Democrats start their quadrennial show in Charlotte.

Obama narrowly won North Carolina in 2008, and scheduled his 2012 convention there in hopes of repeating the unexpected feat. Romney's path to victory is severely complicated unless he puts the state back in the GOP column.

Like any presidential challenger, Romney must do two things: Make voters willing to oust the incumbent, and make himself an acceptable replacement.

In Thursday's address, Romney seemed to assume Americans have already cleared the first hurdle, weary of high unemployment.

"What America needs is jobs, lots of jobs," Romney said. "To the majority of Americans who now believe that the future will not be better than the past, I can guarantee you this: if Barack Obama is re-elected, you will be right."

White House press secretary Jay Carney said Obama's visit to Fort Bliss on Friday will highlight administration efforts to support U.S. service members and their families, both in Iraq and Afghanistan. Those efforts include attempts to combat what Carney called "unseen wounds" of the Iraq and Afghanistan wars, including post-traumatic stress disorder and traumatic brain injury.

Romney avoided the topic of terrorism and wars in Islamic countries, which bedeviled President George W. Bush's final years and helped launch Obama's career. In his big speech Thursday, Romney did not mention Iraq, Afghanistan or terrorism.

___

Associated Press writers Kasie Hunt, Steve Peoples, Philip Elliott, Beth Fouhy, Thomas Beaumont and Julie Mazziotta in Tampa and Jennifer Agiesta and Cal Woodward in Washington contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-08-31-Presidential%20Campaign/id-bc4f7bcbfd8e4a2a86f344a6dbfd32dc

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AusTex Oil Limited (ASX:AOK) Production Well Development Program on Track at Snake River

Sydney, Aug 30, 2012 (ABN Newswire) - United States focused oil & gas produer AusTex Oil Limited (ASX:AOK) (OTCQX:ATXDY) is pleased to update shareholders on its well development program at the company's 100% owned 5,500 acre Snake River Project in Kay County, Oklahoma.

In line with the company's strategy of drilling two new wells each month until Devcember of this year, AusTex is pleased to confirm the Cletus #20-5 in the East Tonkawa Production Hub has reached total depth. Also, spudding of the Blubaugh #20-2, also in the East Tonkawa Production Hub, will occur in the next few days.

Cletus #20-5 well

Drilling on the Cletus #20-5 well successfully reached Total Depth of 4,772 feet. Sample and logs confirmed multiple intervals with hydrocarbons present including the Tonkawa Sand, Cleveland Sand, Layton Sand, Mississippi Lime, Woodford Shale and Wilcox Sand.

Casing has been set and the well will be completed for oil production from the Mississippi Lime interval. The well encountered multiple intervals of porosity within the 340 gross feet of Mississippi Lime intersected including 2 distinct "chert/chat" sections.

Blubaugh #20-2 well

The rig has moved onto the location of the #20-2, also located in the Production Hub 2 area. The well is expected to spud in the next few days and it be the 10th vertical well drilled on the Snake River Project. The #20-2 is targeting the Mississippi Lime interval with an expected TD of 4,800 feet.

Executive Chairman Richard Adrey said: "Our program of drilling two wells each month between now and December is on-track and progressing to plan. As we have previously stated, increasing production from current levels of 300 boepd is our key objective at this time, and our well development program ensures we can substantially grow current production from these levels.

"AusTex is also assessing additional horizontal well participation opportunities and negotiations with interested parties are ongoing. The interest in our projects and our acreage is very encouraging, and confirms the fact that our projects have significant up-tapped value."

AusTex will update shareholders shortly on production rates from new wells that have recently come on stream as reported in the announcement to the Australian Securities Exchange on 22 August 2012.

View the full AusTex Oil announcement incuding Figure 1 at the link below:
http://media.abnnewswire.net/media/en/docs/ASX-AOK-692185.pdf

Source: http://www.abnnewswire.net/press/en/73470/

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marketnewsvideo: Lukoil Oil Company Breaks Below 200-Day Moving Average - Notable for LUKOY PXH: In trading on Thursday, shares o... http://t.co/UVaymkrh

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Source: http://twitter.com/marketnewsvideo/statuses/241203434978693120

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Thursday, August 30, 2012

Families sue over Kansas grain elevator blast

(AP) ? Family members of four people killed in a grain elevator explosion last year in northeast Kansas are suing employees of Bartlett Grain Co., including its current president Bob Knief, less than five months after federal investigators pinned the blame for the blast on the Kansas City, Mo., company.

The wrongful death lawsuits were filed Monday in Jackson County Circuit Court in Missouri on behalf of Bartlett employees Chad Roberts, 20; Ryan Federinko, 21; Curtis Field, 21; and John Burke, 24. They were killed along with two grain inspectors ? Travis Keil, 34, and Darrek Klahr, 43 ? when the Bartlett elevator exploded Oct. 29, 2011, in Atchison, Kan.

"It hurts as bad today as it did then," Roberts' stepfather, Kevin Bock, said Wednesday. "The feelings don't stop. You learn to work through certain things, but they don't stop."

Bock, whose wife is suing on behalf of Roberts, said he encouraged the other families to also sue Bartlett after the Occupational Safety and Health Administration issued a report in April saying the grain-dust explosion could have been prevented if the elevator's operators had addressed hazards known in the industry.

"Bartlett Grain's disregard for the law led to a catastrophic accident and heartbreaking tragedy for the workers who were injured or killed, their families and the agricultural community," U.S. Labor Secretary Hilda Solis said in April in response to the OSHA report, which sought $406,000 in penalties in addition to citations alleging five willful and eight serious safety violations.

Department of Labor spokesman Scott Allen said the company has contested the citations and fine, and it could take up to a year or more for it to go through the administrative review process.

Bartlett officials have called the OSHA findings flawed and vowed to fight the claims.

When contacted for comment on the lawsuits Wednesday, Bartlett provided the same statement it sent out in April criticizing OSHA's report, though it added a paragraph saying it still believes its employees acted reasonably at all times prior to the explosion.

"While we are just seeing the suit and its allegations, it appears to be based on nothing more or less than the OSHA citations, with which we take total exception and which we therefore, certainly have appealed," the company said.

Ed Dougherty, an attorney for the Bocks and one of the other plaintiffs, said the families of Keil and Klahr have obtained attorneys but aren't involved in the lawsuits filed Monday because the men weren't Bartlett employees and their cases will be handled separately.

The Missouri State Fire Marshal's Office issued a preliminary report in October calling the explosion an accident and saying there was no evidence of criminal activity. The OSHA report, though, came down much harder on the grain company.

Among the willful violations, OSHA alleged Bartlett Grain allowed grain dust, which is nine times as explosive as coal dust, to accumulate and used compressed air to remove dust without first shutting down ignition sources. OSHA defines a willful violation as one committed with intentional knowing or voluntary disregard for the law's requirements or with plain indifference to worker safety and health.

The serious violations, defined as those with a substantial probability of death or serious physical harm, include claims that there was a lack of preventative maintenance and that the housekeeping program was deficient because it didn't prevent grain dust accumulations.

Bock said the company was helpful to the families of the victims, but eventually the stream of communication from Bartlett ran dry. He said he hasn't heard anything from the company since receiving a letter in late June informing families of a memorial the company plans to establish overlooking the Missouri River and the grain elevator in Atchison.

Bock criticized the company for not working with the families on the memorial, noting that the elevator isn't a welcome sight for people who lost loved ones there.

"One thing I can say for the families, especially the three families that live in Atchison, is none of them like the location," Bock said. "They don't want to look over at Bartlett when they see this memorial. They're not going to visit a memorial where they have to look over at that elevator."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-08-29-Grain%20Elevator%20Explosion-Lawsuits/id-3accda06580f4a3ebacc01e2b8f0d5d5

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LG Optimus L9 hands-on (video)

LG Optimus L9 handson

Thought LG didn't have any more to add to the L-Style series to offer the world? Behold the L9. Announced yesterday, the device made an appearance on the IFA show room floor this week, boasting a big and bright 4.7-inch IPS display that makes its brethren look downright shrimpy by comparison. In spite of the display size, the phone feels light, with an 8.9-millimeter profile.

It's important to note here that, in spite of being the king of the L-Series, it's still part of a budget lineup, and as such, the phone's body feels a bit plasticky, and the textured rear had a bit of trouble staying snapped in place in the two models (black and white) that we played with. Specwise, we're talking a 1GHz dual-core processor, 1GB of RAM inside, 4GB of storage (expandable via a microSD slot) and a 2,150mAh battery. The handset's rocking Ice Cream Sandwich (4.0.4, to be precise).

The handset's got a fairly nice bezel, with the front-facing camera on the top and a home button on the bottom, flanked by illuminating back and menu touch buttons. A larger, 5MP camera is located on the rear of the device, above the flash. Vodafone has the handset priced at €50.90 subsidized and €340 unsubsidized. Peep a video of the handset, after the break.

Continue reading LG Optimus L9 hands-on (video)

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LG Optimus L9 hands-on (video) originally appeared on Engadget on Thu, 30 Aug 2012 09:07:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/08/30/lg-optimus-l9-hands-on/

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Promotion For Many Small Business Owners | Web Design Box

Internet Marketing for small business is becoming a popular matter. The newest statistics of the US census reveal that in 2012 around twenty one million businesses were Non-employer Companies, in other words entrepreneurs ? one man or one woman shows. And the other 10 Million businesses had 9 or less workers.

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